The only recommendation would be to look at a bunch of script writing tutorials and write one. Then 2, then 3, etc… Then keep writing them until you are confident that it does what you want. To simply clear a few columns is pretty straight forward. If you wanted to clear the contents of columns E and F on Sheet2, this is the script.
function clearAFewColumns() {
var sheet = SpreadsheetApp.getActive().getSheetByName('Sheet2');
var lastRow = sheet.getLastRow();
// Column E = 5; F = 6
sheet.getRange(2, 5, lastRow, 1).clearContent();
sheet.getRange(2, 6, lastRow, 1).clearContent();
}
Do some Google searches on how to add a Box on a sheet, or create a menu item, and have it execute a function.